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M9630188.TXT
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1996-02-27
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Document 0188
DOCN M9630188
TI Analysis of genetic diversity at the arom locus in isolates of
Pneumocystis carinii.
DT 9603
AU Banerji S; Lugli EB; Miller RF; Wakefield AE; Department of Paediatrics,
John Radcliffe Hospital, United; Kingdom.
SO J Eukaryot Microbiol. 1995 Nov-Dec;42(6):675-9. Unique Identifier :
AIDSLINE MED/96081462
AB The DNA sequences of a portion of the 5-enolpyruvyl shikimate phosphate
synthase domain of the arom gene, encoding the pentafunctional AROM
protein, were determined from isolates of Pneumocystis carinii from five
mammalian host species (rat, human, ferret, rabbit and mouse). High
levels of genetic divergence were found among P. carinii derived from
different host species, 7-22% at the DNA sequence level, and 7-26% at
the derived amino acid sequence level. Two separate and distinct
sequences were isolated from infected ferret lungs. Low levels of
divergence were seen in human-derived organisms.
DE Amino Acid Sequence Animal AIDS-Related Opportunistic
Infections/MICROBIOLOGY Base Sequence Bronchoalveolar Lavage
Fluid/MICROBIOLOGY Comparative Study DNA Primers Ferrets *Genes,
Fungal Human Mice Mice, Inbred BALB C Molecular Sequence Data
Pneumocystis carinii/ENZYMOLOGY/*GENETICS/*ISOLATION & PURIF Pneumonia,
Pneumocystis carinii/COMPLICATIONS/*MICROBIOLOGY Polymerase Chain
Reaction Rabbits Rats Rats, Sprague-Dawley Sequence Homology, Amino
Acid Sequence Homology, Nucleic Acid Species Specificity Support,
Non-U.S. Gov't Transferases/BIOSYNTHESIS/*GENETICS *Variation
(Genetics) JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).